Spectral studies on a series of metal ion complexes derived from pyrimidine nucleus, TEM, biological and γ-irradiation effect

• A series of transition metal ion complexes was prepared using different metal ions with a new derivative of thiouracil.
• The complexes were investigated using all possible tools.
• ESR spectrum of Cu(II) complex was carried out before and after γ-irradiation.
• XRD and TEM were carried out to give insight about the nature of the complexes isolated.
• The biological effect of all investigated compounds was studied on different microorganisms.

A series of thiouracil complexes was prepared, all the prepared compounds are investigated by all possible tools. The ligand coordinates towards two central atoms as a neutral hexadentate mode. The octahedral structure was proposed with Ni(II), Pt(IV) and UO2(II) complexes. Square-pyramidal and square planar with VO(II) and Pd(II) complexes, respectively. VO(II) complex was irradiated by using Gamma radiation to through a light on the probability of geometry changes with the effect of radiation. The parameters calculated from ESR spectra before and after γ-irradiation reflect the rigidity of the complex towards the effect. Such may discuss the unaffected biological behavior before and after irradiation. XRD patterns were carried out to emphasis on the nature of the particles and the purity of products. The ligand, Pt(IV) and Pd(II) are found in nanometer range. TEM is a sensitive tool used to justify on the microstructure and surface morphology. All the investigated compounds are in nanorange. TG curves reflect a lower thermal stability of all investigated complexes due to the presence of water of crystallization. Finally, a toxic effect was observed with all investigated complexes towards Gram positive bacterium as well as a resistant behavior was observed with Gram negative bacteria.

The EPR spectrum of Cu(II) complex before and after γ-irradiation which may reflect a change in the structural formula of the complex after irradiation.Figure optionsDownload as PowerPoint slide