Supramolecular aggregates formed by sulfadiazine and sulfisomidine inclusion complexes with α- and β-cyclodextrins

• SDA/α-CD complex self assembled to formed hierarchal morphology.
• SDA/β-CD and SFM/β-CD complexes self assembled to form the nanosheet.
• SFM/α-CD complex self assembled to form nanoporous sheet.
• van der Waals, hydrophobic and hydrogen bonding interactions play a vital role in the self assembling process.

Sulfadiazine (SDA) and sulfisomidine (SFM) inclusion complexes with two cyclodextrins (α-CD and β-CD) are studied in aqueous as well as in solid state. The inclusion complexes are characterized by UV–visible, fluorescence, time correlated single photon counting, FTIR, DSC, PXRD and 1H NMR techniques. The self assembled SDA/CD and SFM/CD inclusion complexes form different types of nano and microstructures. The self assembled nanoparticle morphologies are studied using SEM and TEM techniques. SDA/α-CD complex is formed hierarchal morphology, SDA/β-CD and SFM/β-CD complexes form the nanosheet self assembly. However, SFM/α-CD complex forms nanoporous sheet self assembly. van der Waals, hydrophobic and hydrogen bonding interaction play a vital role in the self assembling process.

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