Spectroscopic, thermal and antitumor investigations of sulfasalazine drug in situ complexation with alkaline earth metal ions

The complexes of sulfasalazine (H3Suz) with some of alkaline metals Mg(II), Ca(II), Sr(II) and Ba(II) have been investigated. Sulfasalazine complexes were synthesized and characterized by spectroscopic tools; infrared spectra, electronic and mass spectra. The IR spectra of the prepared complexes were suggested that the H3Suz behaves as a bi-dentate ligand through the carboxylic and phenolic groups. The molar conductance measurements gave an idea about the non-electrolytic behavior of the H3Suz complexes. The thermal decomposition processes for metal(II) complexes of H3Suz viz: [M(HSuz)(H2O)4] (where M = Mg(II), Ca(II), Sr(II) or Ba(II)) have been accomplished on the basis of TG/DTG and DTA studies, and the formula conforms to the stoichiometry of the complexes based on elemental analysis. The kinetic analyses of the thermal decomposition were studied using the Coats–Redfern and Horowitz–Metzger equations. The antitumor and antimicrobial activities of the H3Suz and their alkaline metal(II) complexes were evaluated.

Mg(II), Ca(II), Sr(II) and Ba(II) sulfasalazine chelation.Figure optionsDownload as PowerPoint slideHighlights
► The complexes of sulfasalazine with some of alkaline metals have been investigated.
► The kinetic analyses of the thermal decomposition were studied.
► The antitumor and antimicrobial activities of the ligand and their complexes were evaluated.