کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1234967 968840 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of fluorescence characteristics of the charge-transfer reaction of quinolone agents with bromanil
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Study of fluorescence characteristics of the charge-transfer reaction of quinolone agents with bromanil
چکیده انگلیسی

A spectrofluorimetric method was discussed for the determination of three antibacterial quinolone derivatives, ofloxacin (OFL), norfloxacin (NOR) and ciprofloxacin (CIP) through charge-transfer complexation (CTC) with 2,3,5,6-tetrabromo-1,4-benzoquinone (bromanil, TBBQ). The method was based on the reaction of these drugs as n-electron donors with the π-acceptor TBBQ. TBBQ was found to react with these drugs to produce a kind of yellow complexes and the fluorescence intensities of the complexes were enhanced by 29–36 times more than those of the corresponding monomers. UV–vis, 1H NMR and XPS techniques were used to study the complexes formed. The various experimental parameters affecting the fluorescence intensity were studied and optimized. Under optimal reaction conditions, the rectilinear calibration graphs were obtained in the concentration range of 0.021–2.42 μg mL−1, 0.017–2.63 μg mL−1 and 0.019–2.14 μg mL−1 for OFL, NOR and CIP, respectively. The methods developed were applied successfully to the determination of the subject drugs in their pharmaceutical dosage forms with good precision and accuracy compared to official and reported methods as revealed by t- and F-tests.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 71, Issue 5, January 2009, Pages 1769–1775
نویسندگان
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