کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1246269 | 969750 | 2006 | 8 صفحه PDF | دانلود رایگان |
A simple chemiluminometric method using flow injection has been developed for the determination of paracetamol (acetaminophen), based on the chemiluminescence produced by the reduction of tris(2,2′-bipyridyl)ruthenium(III). The latter is obtained by oxidation of tris(2,2′-bipyridyl)ruthenium(II) by potassium permanganate in dilute sulphuric acid in the presence of paracetamol. A standard or sample solution was injected into the ruthenium(II) stream (flow rate 1.5 ml min−1) which was then merged with potassium permanganate in dilute sulphuric acid stream (flow rate 0.5 ml min−1). The chemiluminescence intensity is enhanced by the presence of manganese(II) ions. Under the optimum conditions, a linear calibration graph was obtained over the range of 0.3–50.0 μg ml−1 and the detection limit was 0.2 μg ml−1 (s/n = 3). The relative standard deviation of the proposed method calculated from 20 replicate injections of 5.0 μg ml−1 paracetamol was 1.1%. The sample throughput was 90 h−1. The method was successfully applied to the determination of paracetamol in commercial pharmaceutical formulations.
Journal: Talanta - Volume 69, Issue 4, 15 June 2006, Pages 976–983