کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1247867 1495897 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment
چکیده انگلیسی


• Extraction strategies are vital for recovering both neutral and ionic analytes.
• Concentration and derivatization assist analysis of transient intermediates.
• Coupled instrumentation decreases challenges from complex environmental matrices.
• Mass spectrometry elucidation and QSAR prediction identify novel metabolites.
• Challenges on studying alternative polyfluoroalkyl substances.

Biotransformation of polyfluoroalkyl precursors contributes in part to the perfluoroalkyl carboxylates and sulfonates detected in the global environment and biota. Robust sample preparation and sensitive analytical techniques for maximum analyte recovery are essential to identify and to quantify biotransformation products often present at low levels in environmental matrices and experimental systems. This critical review covers current sample-preparation and analytical methods, including extraction, concentration, clean-up and derivatization, mass spectrometry coupled to gas or liquid chromatography, and radioisotope labeling and tracking techniques. We also critically review methodologies for molecular structural elucidation and in-silico prediction of potential transformation products. We describe current knowledge gaps and challenges in studying novel alternative polyfluoroalkyl substances. We discuss future trends on utilizing advanced analytical techniques.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 67, April 2015, Pages 167–178
نویسندگان
, , , , ,