کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1249353 | 970632 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics](/preview/png/1249353.png)
چکیده انگلیسی
Gas chromatography combined with mass spectrometry (GC-MS), in particular derivatization-based GC-MS, is one of the most commonly used analytical methods in metabolomics. However, experiment-derived variations and originations of chromatographic peaks are two fundamental issues that could influence interpretation of metabolic pathways. Here, we focus on some pitfalls and limitations, especially the commonly ignored multi-origination and multi-peak phenomena in derivatization-based GC-MS metabolomics. We use examples to illustrate that ignoring these two factors could lead to wrong interpretations of results and serious metabolic implications. We also discuss strategies to overcome some of these confounding factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 29, Issue 3, March 2010, Pages 269–280
Journal: TrAC Trends in Analytical Chemistry - Volume 29, Issue 3, March 2010, Pages 269–280
نویسندگان
Fengguo Xu, Li Zou, Choon Nam Ong, Li Zou, Choon Nam Ong, Choon Nam Ong,