A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging

A rhodamine-based sensor has been developed for the detection of mercuric ions. The colorimetric and fluorescence responses, allowing naked-eye detections, are based on Hg2+-induced opening of the rhodamine spirocycle. Among all the testes ions, only Hg2+ generated a significant fluorescence enhancement of up to 300-fold, with a bright yellow–green emission. This sensor was a low toxic compound, and was successfully applied in the in vivo imaging of Hg2+ in Spill 2 cells and C. elegans. This approach provides a sensitive and accurate method for the estimation of Hg2+ in environmental, tobacco and biological applications.

A rhodamine-based sensor has been developed for the detection of mercuric ions, with a significant fluorescence enhancement of up to 300-fold. This sensor was a low toxic compound, and was successfully applied in the in vivo imaging of Hg2+ in Spill 2 cells and C. elegans.Figure optionsDownload as PowerPoint slide