Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells

Two new compounds, 11,11′-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa. The chemical structures of the isolated compounds were elucidated using different spectroscopic methods. In addition, the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562/A02 cells. Compounds 1, 8, and 9 were endowed with remarkable MDR reversing effects.

Two new compounds, 11,11′-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), were isolated and identified from the whole grass of Cicuta virosa. Compounds 1, 8, and 9 were endowed with remarkable MDR reversing effects.Figure optionsDownload as PowerPoint slide