کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254368 1379131 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and pharmacological activity evaluation of curcumin derivatives
ترجمه فارسی عنوان
سنتز و ارزیابی فعالیت های داروسازی مشتقات کورکومین
کلمات کلیدی
دی هیدروپیریمیدینون کورکومین / تیونز / امینین، اشعه مایکروویو، ظرفیت آنتی اکسیدان، فعالیت ضد التهابی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a–o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.

A series of curcumin dihydropyrimidinone derivatives have been synthesized using modified procedure and evaluated for antioxidant and anti-inflammatory activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 27, Issue 7, July 2016, Pages 1067–1072
نویسندگان
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