کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254465 971376 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel and green synthesis of indolone-N-amino acid derivatives via the Passerini three-component reactions in water
ترجمه فارسی عنوان
سنتز جدید و سبز مشتقات اسید آمینه Indolone-N از طریق واکنش های سه جزء Passerini در آب
کلمات کلیدی
Passerini واکنش سه جزء؛ Indolone-N-amino acid؛ سنتز سبز؛ Heterocycles؛ ایزوسیانید
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

A green Passerini three-component reaction of 2-(4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid with alkyl or aryl isocyanides and aldehydes was reported under aqueous conditions at 35 °C for 1 h, and 21 indolone-N-amino acid derivatives were prepared in high yields of 42%–99%. Their structures were characterized by IR, ESI–MS, NMR and elemental analysis, and the possible mechanisms have been also proposed. The highly efficient and eco-friendly method provides a facile access to a library of indolone-N-amino acid derivatives for future research on bioactivity screening.

A series of 21 indolone-N-amino acid derivatives have been synthesized through an aqueous Passerini three-component reaction in 42%–99% yields. The highly efficient and eco-friendly method provides a facile access to a library of indolone-N-amino acid derivatives for future research on bioactivity screening.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 27, Issue 3, March 2016, Pages 345–348
نویسندگان
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