Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and α-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with α-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.

Three-component reactions of pyridines and dialkyl acetylenedicarboxylates with different α-halo ketones led to chemoselective synthesis of functionalized indolizines in good to high yields under mild reaction conditions. All the reactions gave the desired indolizines without formation of any [1,3]-oxazines.Figure optionsDownload as PowerPoint slide