A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of (A-taphos)2PdCl2 as a catalyst in combination with CsF as base and DME-H2O (4:1) as the solvent system at 100 °C procured the diaryls in acceptable to excellent yields. Prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved.Figure optionsDownload as PowerPoint slide