Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.

In this paper, we report a simple method for the synthesis of 5-alkynyl-1,2,3-triazoles from various alkynes and azides. The transformation of 5-alkynyl-1,2,3-triazoles to structurally diverse 5-functionalized-1,2,3-triazoles via oxidation, reduction and condensation reactions was explored.Figure optionsDownload as PowerPoint slide