Cu(II)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone

A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones, without the addition of any ligand and additive, has been developed. The domino reaction achieved N-(α-substituted)benzylation, benzylic CH amidation, and CC (or CH) bond cleavage.

A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones, without the addition of any ligand and additive, has been developed. The domino reaction achieved N-(α-substituted)benzylation, benzylic CH amidation, and carbon–carbon (or carbon–hydrogen) bond cleavage.Figure optionsDownload as PowerPoint slide