Preparation of fenofibrate nanoparticles by combined stirred media milling and ultrasonication method

• Nanoparticles were prepared combining stirred media milling and ultrasonication.
• The effects of sonication time, power on product particle sizes were evaluated.
• Prepared fenofibrate nanoparticles exhibited excellent stability.

The production of fenofibrate nanoparticles combining stirred media milling and ultrasonication method was investigated in the current work. The fenofibrate drug sample was first wet milled in stirred media mill for different times and subsequently processed by ultrasonication. The effects of ultrasonication time, power on final product particle sizes were studied. The pre milling by stirred media milling was resulted into reduction of comminution resistance of material. Subsequent treatment by ultrasonication produced smaller particles than obtained by stirred media milling alone. The resulting nanoparticles were found to exhibit excellent stability as investigated by particle size, zeta potential, and multiple light scattering measurement techniques. Further, qualities of nanoparticles obtained by combined approach were characterized by TEM and XRD analysis.