کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1301726 1498919 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Host–guest interactions in tetramethyl-cucurbit[6]uril with anti-tuberculosis drug isoniazid
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Host–guest interactions in tetramethyl-cucurbit[6]uril with anti-tuberculosis drug isoniazid
چکیده انگلیسی


• Our studies represent an important strategy to manipulate physicochemical properties of pharmaceutical agents by host-guest interactions.
• A supramolecular strategy was used to chemically investigate the binding behaviours of the host TMeQ[6] with the guest INH.
• The first example of structurally characterized cucurbit[n]uril-isoniazid host-guest complexes.

A novel supramolecular host–guest complex of anti-tuberculosis drug isoniazid (INH) with symmetrical α,α′,δ,δ′-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been investigated using 1H NMR spectroscopy methods, mass spectrometer and single-crystal X-ray diffraction analysis. The result revealed that the INH guest is located the portal of the TMeQ[6] host in both the solutions and the solid state. The driving forces for the association between the guest INH and the host TMeQ[6] are made by a balance between hydrogen bonding interactions and ion-dipole interactions.

A novel supramolecular host–guest complex of anti-tuberculosis drug isoniazid (INH) with symmetrical α,α′,δ,δ′-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been investigated using 1H NMR spectroscopy methods, mass spectrometer and single-crystal X-ray diffraction analysis. The result revealed that the INH guest is located the portal of the TMeQ[6] host in both the solutions and the solid state.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganic Chemistry Communications - Volume 71, September 2016, Pages 68–72
نویسندگان
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