Unprecedented preparation of bis-Schiff bases and their manganese(III) complexes with urease inhibitory activity

Two new thiocyanato-coordinated manganese(III) complexes with bis-Schiff bases have been unprecedented prepared from N-ethylethane-1,2-diamine and N-(2-hydroxyethyl)ethane-1,2-diamine as the starting materials with equimolar quantities of 4-methoxysalicylaldehyde and 3-ethoxysalicylaldehyde, respectively. It was found that the reaction can process only in the presence of manganese salts and ammonium thiocyanate. The urease inhibitory activity of the complexes was tested.

Two new thiocyanato-coordinated manganese(III) complexes with bis-Schiff bases have been unprecedented prepared from mono-Schiff bases. The urease inhibitory activity of the complexes was tested.Figure optionsDownload as PowerPoint slideHighlights
► Two new manganese(III) complexes with bis-Schiff bases have been unprecedented prepared from mono-Schiff bases.
► The complexes have been characterized by single crystal X-ray diffraction.
► The complexes show urease inhibitory activity.
► The molecular docking study of the complexes with urease was performed.