Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands

• Water soluble Pt complexes with seleno ethers have been prepared and characterized.
• Detailed characterization including single crystal XRD and NMR is reported.
• These complexes show hydrogen bonded 2D supra-molecular network.
• Their antitumor properties are similar to cisplatin.

A series of water soluble platinum(II) complexes of general formulae [Pt(en)(L)][NO3]2, [Pt(NH3)2(L)][NO3]2 [en = ethylenediamine; L = dmpzC6H4Se(CH2)nCOOH or dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)], [Pt(en)(L)][NO3][OH]·H2O [L = dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)] and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O have been synthesized. They were characterized by microanalyses, IR, NMR (1H, 13C{1H}, 77Se{1H} and 195Pt{1H}) spectroscopy. Molecular structures of [Pt(en)(dmpzCH2CH2SeCH2COOH)][NO3][OH]·H2O and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O were determined unambiguously by single crystal X-ray diffraction analyses. The cytotoxicity of these complexes has been evaluated against human colon (HT29, Colo205), ovarian (A2780) and bladder (T24) cancer cell lines and compared with the activity of cisplatin and adriamycin.

Water soluble platinum(II) complexes of general formulae [Pt(en)(L)][NO3]2, [Pt(NH3)2(L)][NO3]2, [Pt(en)(L)][NO3][OH]·H2O, [Pt(NH3)2(L)][NO3][OH]·H2O and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O have been synthesized (en = etheylenediamine; dmpz = 3,5-dimethylpyrazole). Molecular structures of [Pt(en)(dmpzCH2CH2SeCH2COOH)][NO3][OH]·H2O and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O are described. The antitumor activity of these complexes on human cancer cell lines (HT29 and Colo205) is reported.Figure optionsDownload as PowerPoint slide