New PTA (1,3,5-triaza 7-phosphaadamantane) derivatives associating zwitterionic structure and coordinative ability

The reactions of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane) with 1,3-propanesultone or 1,4-butanesultone gave the water soluble zwitterionic derivatives PTA+C3H6SO3− (1), PTA+C4H8SO3− (2), HMTA+C3H6SO3− (3) and HMTA+C4H8SO3− (4). The crystal structure of HMTA+C3H6SO3 is reported. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested in two human ovarian cancer cell lines, A2780 and SKOV3.

Hydrosoluble zwitterionic derivatives of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane), 1–4, have been prepared and characterised. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested over two human ovarian cancer cell lines, A2780 and SKOV3.Figure optionsDownload as PowerPoint slideHighlights
► New hydrosoluble zwitterionic PTA and HMTA derivatives have been prepared.
► Their coordinative ability with platinum and ruthenium has been investigated.
► The antiproliferative activity on tumoral human cell lines has been tested.