کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1313493 | 1499315 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Nitrosation of gem-bromofluorocyclopropanes is studied.
• A nitrosyl chloride sulfur trioxide adduct is used as a reagent.
• 5-fluoro- and 5-bromoalkylisoxazoles were synthesized.
• Fluorinated cyclopropanes exhibited excellent chemoselectivity for 5-fluoroisoxazoles.
A method for the synthesis of 5-fluoro- and 5-bromoalkylisoxazoles via nitrosation of alkylated gem-dihalocyclopropanes with a nitrosyl chloride sulfur trioxide adduct has been developed. In the case of bromofluorocyclopropanes the reaction proceeded with excellent chemoselectivity thus providing exclusively 5-fluoroisoxazoles.
Figure optionsDownload as PowerPoint slideA method for the synthesis of 5-fluoro- and 5-bromoalkylisoxazoles via nitrosation of alkylated gem-dihalocyclopropanes with a nitrosyl chloride sulfur trioxide adduct has been developed. In the case of bromofluorocyclopropanes the reaction proceeded with excellent chemoselectivity thus providing exclusively 5-fluoroisoxazoles.
Journal: Journal of Fluorine Chemistry - Volume 185, May 2016, Pages 201–205