کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1317970 | 976620 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histamine modified 2â²-deoxyriboadenosine - Potential copper binding site in DNAzymes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Copper(II) complexes of histamine modified 2â²-deoxyriboadenosine (N-[(9-β-D-2â²-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV-visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2â²-deoxyriboadenosine could chelate efficiently copper(II) ions if it were incorporated into DNAzyme sequence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 104, Issue 5, May 2010, Pages 570-575
Journal: Journal of Inorganic Biochemistry - Volume 104, Issue 5, May 2010, Pages 570-575
نویسندگان
Elżbieta Åodyga-ChruÅciÅska, Elżbieta Sochacka, Damian Smuga, Longin ChruÅciÅski, Giovanni Micera, Daniele Sanna, Monika Turek, Monika GÄ
siorkiewicz,