Organic/inorganic salting-in/salting-out agents as promoters of Pd-catalysed ligand free synthesis of biaryls in water

• All the reactions are carried out in water medium at room temperature.
• It is a ligand free approach.
• Small quantities of ionic additive are required for enhancing the reaction rate.
• Good to excellent yields were obtained within a very short reaction time.
• Overall, the methodology is quick, versatile and highly efficient.

Biaryls were synthesized using Pd-catalyzed Suzuki–Miyaura cross coupling reactions of aryl halides with aryl boronic acids in water in the presence of organic/inorganic additives as promoters. The coupling reactions, carried out in absence of ligand, proceed in good to excellent yields with easy product isolation and in relatively shorter reaction time.

Suzuki-Miyaura cross coupling reactions, carried out in absence of ligand, proceed in good to excellent yields with easy product isolation and in relatively shorter reaction time in presence of salting-in and salting-out additives as promoters.Figure optionsDownload as PowerPoint slide