Preparation and structural characterization of hetero-dinuclear Schiff base copper(II)–zinc(II) complexes and their inhibition studies on Helicobacter pylori urease

A series of hetero-dinuclear CuII–ZnII complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L1, L2, L3, L4 and L5 are the deprotonated forms of N,N′-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N′-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N′-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N′-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N′-bis(salicylidene)-1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 μM. The molecular docking study of the complexes with the Helicobacter pylori urease was performed.

A series of hetero-dinuclear CuII–ZnII complexes have been prepared and structurally characterized. The urease inhibitory activities were studied. Two of the complexes exhibit effective activity.Figure optionsDownload as PowerPoint slideHighlights
► A series of hetero-dinuclear Schiff base copper(II)–zinc(II) complexes have been synthesized.
► The complexes have been characterized by elemental analyses, IR spectra and single crystal X-ray diffraction.
► Two complexes show effective inhibitory activity against Helicobacter pylori urease.
► A molecular docking study of the complexes with the H. pylori urease was performed.