Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.

A series of bi- and trinuclear palladium(II) and platinum(II) salicylaldimine thiosemicarbazone complexes been synthesized and characterized by NMR and IR spectroscopies, ESI-mass spectrometry, and elemental analyses. The in vitro anticancer studies of selected complexes were evaluated against the WHCO1 oesophageal cancer cell line.Figure optionsDownload as PowerPoint slideHighlights
► Salicylaldimine di- and trithiosemicarbazone ligands have been prepared.
► Polynuclear palladium(II) and platinum(II) complexes were synthesized containing thiosemicarbazone ligands.
► Selected complexes were evaluated as anticancer drugs.