کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1339091 | 979692 | 2010 | 6 صفحه PDF | دانلود رایگان |
The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)]·nH2O (S,S-eddp = ethylenediamine-N,N′-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N′-di-S,S-2-propanoic acid (H2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl2]·4H2O and uns-cis-[Pt(S,S-eddp)Br2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin.
The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N′-di-S,S-2-propanoic acid (H2-S,S-eddp). The crystal structures of the complex units are given.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 29, Issue 8, 27 May 2010, Pages 1933–1938