کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1354030 1500374 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular Cloning and Homology Modeling of Novel Tyrosylprotein Sulfotransferase of Marine Mollusk
ترجمه فارسی عنوان
کلونینگ مولکولی و مدل‌سازی هومولوژی Tyrosylprotein Sulfotransferase جدید صدف دریایی
کلمات کلیدی
TPST، tyrosylprotein sulfotransferases؛ 3'-phosphoadenosine-5'-phosphosulfate؛ LsTPST، سولفوترانسفراز تیروزیل پروتئین از Littorina sitkanaTyrosylprotein sulfotransferase؛ TPST؛ اصلاح پس از ترجمه؛ صدف دریایی؛ Littorina sitkana
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

The gene of tyrosylprotein sulfotransferase, which was discovered in mammals, has been widely found in marine mollusk Littorina sitkana. High conservation of this gene indicates the functional importance of TPST in the metabolism of the living world. The cDNA encoding TPST in the mollusk was cloned and sequenced, and the enzyme was assigned on the basis of amino acid sequence similarity as tyrosylprotein sulfotransferase-2 (TPST-2). The putative homology model for the catalytic domain of TPST from L. sitkana was constructed according to crystal structure of the catalytic domain of the human TPST-2. The putative model of dimer structure showed that the active site involved two monomers and the dimer contains two active centers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Achievements in the Life Sciences - Volume 10, Issue 1, June 2016, Pages 118–124
نویسندگان
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