کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355103 | 1500454 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
• Indole Mannich base derivatives.
• ROS.
• Nitric oxide.
• Cytokine inhibition.
The synthetic indole Mannich bases 1–13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 60, June 2015, Pages 118–122
Journal: Bioorganic Chemistry - Volume 60, June 2015, Pages 118–122
نویسندگان
M. Ahmed Mesaik, Khalid Mohammed Khan, Fazal Rahim, Muhammad Taha, Syed Moazzam Haider, Shahnaz Perveen, Ahmed Shukralla Khalid, Omer M. Abdalla, Samreen Soomro, Wolfgang Voelter,