کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360943 | 981453 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of novel 2′,3′-dideoxy-4′-selenonucleosides as potential antiviral agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
On the basis of potent anti-HIV activity of 2’,3’-dideoxynucleosides (ddNs), their bioisosteric analogues, 2’,3’-dideoxy-4’-selenonucleosides (4’-seleno-ddNs) were first synthesized from a chiral template, d-glutamic acid using stereoselective ring-closure reaction of the dimesylate with Se2− and Pummerer type condensation of the selenoxide with nucleobases as key steps. X-ray crystallographic analysis indicated that 4’-seleno-ddNs adopted the same C2’-endo/C3’-exo (South) conformation as anti-HIV active ddNs, but did not show anti-HIV activity, indicating that RT seems to prefer the C2’-exo/C3’-endo (North) conformation on binding with their triphosphates.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 23, 1 December 2008, Pages 9891–9897
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 23, 1 December 2008, Pages 9891–9897
نویسندگان
Lak Shin Jeong, Yoo Na Choi, Dilip K. Tosh, Won Jun Choi, Hea Ok Kim, Jungwon Choi,