Efficient synthesis and biological evaluation of two modafinil analogues

Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality.

Non classical bioisosters of modafinil were synthesized through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality, and evaluated for their effects on the spontaneous and the electrically-evoked tritiated serotonin ([3H]5-HT) efflux from rat cortical slices.Figure optionsDownload as PowerPoint slide