Catalytic Pictet–Spengler reactions using Yb(OTf)3

The catalytic Pictet–Spengler reactions proceeded in high yields with high regioselectivity in the presence of a catalytic amount of Yb(OTf)3 and a dehydrating agent at room temperature. High regioselectivities were obtained in these reactions, and it is suggested that the reactions proceeded under kinetic control.

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