کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363195 | 981506 | 2005 | 5 صفحه PDF | دانلود رایگان |
The anionic H2TPPS porphyrin and its copper derivative, CuTPPS, form in aqueous solution hetero-aggregates with the cationic H2T4 porphyrin and its copper derivative, CuT4. In the presence of poly-l-glutamate, at pH 4.0, a CD signal appears in the Soret region of the spectrum, indicating that the polypeptide has induced chirality into the structure of the aggregates. These species exhibit remarkable inertness due to the strength and number of the coulombic interactions between the anionic and the cationic porphyrins. This property allows them to preserve the chiral structure, even when the matrix changes or loses its chiral conformation, demonstrating that these aggregates are capable of memorizing the chiral information. The remarkable properties of the title systems may find various applications (chiral amplification, discrimination, and separation) that, on the other hand, require a more strict control of the aggregate dimension. Here, we show that the central copper of these macrocycles is crucial for determining the aggregate dimension.
The central copper ion is capable of modulating the extension of the aggregates formed by oppositely charged porphyrins in aqueous solution without preventing the aggregates’ capability to memorize the chiral information borrowed by the α-helical polyglutamate.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 17, 1 September 2005, Pages 5159–5163