Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

The structure–activity relationship of triterpenoids, which isolated from the ethanol extract if Ganoderma lucidum, is reported. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.Figure optionsDownload as PowerPoint slide