کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364405 | 981536 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage intermediates. Detailed examination of the amine substituents at the C2′ position of the pyrimidine and C7 position of the core pyrazolopyridine is described. The antiviral data suggests that non-polar amines are preferred for optimal activity. Additionally, the 2′ position has been shown to require an NH group to retain activity levels similar to that of the gold standard acyclovir.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 7, 1 April 2005, Pages 2397–2411
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 7, 1 April 2005, Pages 2397–2411
نویسندگان
Brian A. Johns, Kristjan S. Gudmundsson, Elizabeth M. Turner, Scott H. Allen, Vicente A. Samano, John A. Ray, George A. Freeman, F. Leslie Boyd Jr., Connie J. Sexton, Dean W. Selleseth, Katrina L. Creech, Kelly R. Moniri,