New supramolecular metallo-terpyridine carboxymethyl cellulose derivatives with antimicrobial properties

• New water soluble supramolecular cellulose derivative was prepared.
• Carboxymethyl cellulose was reacted with CuII–terpyridine complex.
• The prepared CMC–CuII–terpyridine derivative has antibacterial properties.

Preparation of a new water-soluble, cellulose derivative via a supramolecular route is presented. In a one-step procedure, carboxymethyl cellulose (CMC) was reacted with the Cu(BF4)2 complex of 4′-chloro[2,2′:6′,2″]terpyridine to generate the desired CMC–CuII–terpyridine derivative. This polymeric salt was characterized by elemental analysis, ultraviolet–visible spectroscopy (UV–visible), Fourier transform infrared (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), rheological properties measurements, thermogravimetric analysis (TGA), dynamic mechanical thermal analysis (DMTA), and tensile strength properties testing. In addition, antimicrobial properties were demonstrated against Gram-positive bacteria (Staphylococcus aureus and Streptococcus thermophilus), Gram-negative bacteria (Escherichia coli), and yeast (Saccharomyces cervisiae). The minimum inhibitory concentration of the prepared metallo-terpyridine CMC derivative against the studied microorganisms ranged from 6 to 8 mg/L to achieve ≥90% of microbial growth inhibition.