کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1386982 982542 2017 6 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)
ترجمه فارسی عنوان
سنتز مناسب از ترکیبات C-galactofuranosylic (C-galactofuranosides)
کلمات کلیدی
Galactofuranose؛ ترکیبات C-Glycosylic؛ گلیکوزیدهای C ؛ سیانودار کردن
Galactofuranose; C-Glycosylic compounds; C-Glycosides; Cyanation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Galactofuranose sugar units are essential for the production of the cell coat of many pathogenic microorganisms. This sugar is not found in mammals, and so compounds that may interfere with the biosynthetic processing of this sugar unit provide interesting targets for drug design. This paper describes the use of a cyanation reaction for the production of a one-carbon extension of a galactofuranosylic unit at C-1, giving 2,5-anhydro-3,4,6,7-tetra-O-benzoyl-d-glycero-l-manno-heptononitrile. A procedure for the efficient hydrolysis of the introduced nitrile group to produce the methyl ester is reported, along with procedures for the synthesis of both the corresponding α,β-unsaturated, and 3-deoxy ester derivatives.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 337, Issues 21–23, 19 November 2002, Pages 2017–2022
نویسندگان
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