کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1388812 | 1500881 | 2013 | 5 صفحه PDF | دانلود رایگان |
Although different protected d-glucuronals are used as precursors for the preparation of many compounds, standard procedures and large-scale syntheses are still not described in the literature. In the course of the development of different protected d-glucuronyl donors we developed several versatile methods that can be used for fast and reproducible preparation of large amounts of the key intermediates. d-Glucuronolactone was converted to methyl 3,4-di-O-acetyl-d-glucuronal applying a novel one-pot protocol, which allowed for large-scale synthesis. Introduction of silyl and benzyl groups was achieved using optimized procedures. Furthermore 3,4,6-tri-O-acetyl-d-glucal was used as starting material for an improved preparation of benzyl protected d-glucuronal, which significantly accelerates and simplifies similar methods described in the literature.
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► Large-scale synthesis of methyl 3,4-di-O-acetyl-d-glucuronal.
► Different protected glucuronals were prepared using optimized procedures.
► Silyl and benzyl protected glucuronals were prepared as useful precursors.
► TEMPO/BAIB-mediated oxidation was applied to glycals.
Journal: Carbohydrate Research - Volume 370, 5 April 2013, Pages 19–23