Isolation and characterization of new minor triterpenoid saponins from the buds of Lonicera macranthoides

Three new minor compounds, 18-oleanene (1), lupine (2), and 12-oleanene (3) type triterpenoid saponins, along with four major known triterpenoid saponins were isolated from the buds of Lonicera macranthoides. Their structures were elucidated by spectroscopic and chemical analyses. 18-oleanene and lupine-type triterpenoid saponins were first isolated from this plant. The isolated compounds were evaluated for their cytotoxic activities against HSC-2 cells.

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► Three new minor triterpenoid saponins were isolated from the buds of Lonicera macranthoides.
► The structures of the new compounds were elucidated as 18-oleanene, lupine, and 12-oleanene type triterpenoid saponin.
► The 18-oleanene and lupine type triterpenoid saponins were isolated for the first time from Lonicera macranthoides.