کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1389307 | 982863 | 2007 | 8 صفحه PDF | دانلود رایگان |
Modified heparin disaccharides were obtained by the alkaline treatment of a solution containing the disulfated heparin disaccharide ΔHexA-α-(1→4)-d-GlcNSO3,6SO3. Their structures were characterized by one- and two-dimensional NMR spectroscopy: ΔHexA-α-(1→4)-1,6-anhydro-GlcNSO3, ΔHexA-α-(1→4)-1,6-anhydro-ManNSO3 and ΔHexA-α-(1→4)-ManNSO3,6OSO3. NMR spectroscopy, in combination with HPLC, provided the composition of the mixture. Characteristic NMR signals of the disaccharides were identified, even at low levels, in a high field of 1H–13C correlation NMR spectra (HSQC) of a low molecular weight heparin (LMWH) obtained by β-elimination (alkaline hydrolysis) of heparin benzyl ester, providing a more complete structural profile of this class of compounds.
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Journal: Carbohydrate Research - Volume 342, Issue 6, 7 May 2007, Pages 835–842