Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.

Novel 5-substituted Thiazolidine-2,4-dione derivatives linked to pharmacophoric thiazole, triazole and oxadiazole moieties having a central flat phenyl ring with one/two carbon spacer linked to heteroatomwere synthesized. The title compounds were characterized by analytical and spectral methods. Further these compounds were evaluated for hypoglycemic and hypolipidemic activities.Figure optionsDownload as PowerPoint slideHighlights
► Novel thiazole, triazole and oxadiazole containing thiazolidinediones were synthesized.
► These compounds were screened invivo for hypoglycemic and hypolipidemic activities.
► Compound 10h, 11c and 11d displayed good activity.