کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1393239 | 1501195 | 2009 | 11 صفحه PDF | دانلود رایگان |
Using Gossypol (GOS) extracted from cotton seeds, a series of its Schiff bases (1–18) and hydrazones (19–27) have been synthesized and evaluated for their antimicrobial activities against Gram-positive bacteria, Gram-negative bacteria and yeast-like organisms. Of the 27 aza-derivatives of gossypol, 11 have been found active against the microorganisms tested, similar to gossypol. Crystal structures of the new Schiff base (compound 7) and hydrazone (compound 25) of gossypol reveal the presence of two different tautomers within two types of the aza-derivatives studied. The newly synthesized aza-derivatives of gossypol are characterized by the FT-IR, NMR and MS methods.
9 Gossypol hydrazones and 18 gossypol Schiff bases were prepared and evaluated for their antibacterial activity.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 11, November 2009, Pages 4393–4403