Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles

A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (10–13) and isoxazoles (14, 15) were prepared from the synthetically vulnerable intermediate E-styrylsulfonylacetic acid methyl ester (1) and studied their antioxidant activity.

A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (10–13) and isoxazoles (14, 15) were prepared from the synthetically vulnerable intermediate E-styrylsulfonylacetic acid methyl ester (1) and studied their antioxidant activity.Figure optionsDownload as PowerPoint slideHighlights
► A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles were prepared.
► The compound isoxazole in combination with oxazoline exhibited greater antioxidant activity.
► Presence of electron donating substituents on the aromatic ring enhances the activity.