کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1394585 | 1501172 | 2011 | 6 صفحه PDF | دانلود رایگان |
Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.
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► Bioassay guided fractionation led to the discovery of antidyslipidemic clerodane diterpene 1.
► Studies indicate it to be a new structural class of HMG-CoA reductase inhibitor.
► It exhibited better lipid lowering activity than the standard drug Lovastatin.
► The in vivo effects of 1 corroborated well with its molecular docking and also with its pharmacokinetic analysis.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 10, October 2011, Pages 5206–5211