3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

• 3-Hydrazinoindolin-2-one is the main scaffold in an array of anticancer agents.
• Anticancer agents derived from 3-hydrazinoindolin-2-one moiety were chemically classified.
• Various targets for anticancer agents derived from 3-hydrazinoindolin-2-one moiety were highlighted.

Isatin is a well acknowledged pharmacophore in many clinically approved drugs used for treatment of cancer. 3-Hydrazinoindolin-2-one, as a derivative of isatin, represents a pharmacophore of an important class of biologically active pharmaceutical agents by virtue of their diverse biological activities. In this review, anticancer activity will be on focus for compounds derived from 3-hydrazinoindolin-2-one. They are classified according to their chemical structure into nine different classes. In each class, different compounds were browsed, showing their anticancer activity and their potential targets. Moreover, crystallographic data or docking studies were highlighted for some compounds, when available, to provide a deep understanding of their mechanisms of action.

3-Hydrazinoindolin-2-one is the scaffold of choice for nine classes of compounds with significant antitumor activity. The mechanisms of anticancer activity, beside the crystallographic data of different targets or docking studies were highlighted when available.Figure optionsDownload as PowerPoint slide