کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1394950 | 1501094 | 2016 | 9 صفحه PDF | دانلود رایگان |
• We have synthesized pyrrolyl and pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines.
• Compounds (4, 5) displayed slightly higher antimicrobial activity than the respective bis heterocyclic systems (6-11).
• In all the tested compounds, 5c showed greater antimicrobial activity.
A new class of mono and bis heterocycles - styryl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines, pyrrolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines and pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines were prepared from the synthetic intermediate Z-styrylsulfonylacetic acid adopting simple and well versed synthetic methodologies and studied their antimicrobial activity. Amongst all the tested compounds styryl thiadiazole 5c exhibited promising antimicrobial activity against Pseudomonas aeruginosa and Penicillium chrysogenum.
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Journal: European Journal of Medicinal Chemistry - Volume 122, 21 October 2016, Pages 647–655