Clubbed triazoles: A novel approach to antitubercular drugs

In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be a severe problem. Thus with the aim of developing novel molecules with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance, herein we report the synthesis of thiazolyl triazole derivatives, starting from ethyl acetoacetate, by microwave organic reaction enhancement method (MORE) and results of investigations of their antimycobacterial and antimicrobial activities. Many compounds have shown promising activity while others were inactive.

The increasing incidence of infectious disease in both developed and developing countries is most alarming. The second aspect contributing to microbial infections is the rise in the occurrence of drug resistant strains of many microbes like that of malaria, tuberculosis etc. Therefore, there is an urgent need for the design, synthesis, and assay of new potential antimicrobial drugs. The present manuscript discusses about the microwave assisted synthesis and antitubercular screening of novel derivatives.Figure optionsDownload as PowerPoint slide