In vivo insulin-mimetic activity of [N,N′-1,3-propyl-bis(salicyladimine)]oxovanadium(IV)

[N,N′-1,3-Propyl-bis(salicyladimine)]oxovanadium (IV) - an oxovanadium complex has been tested for bioactivity as an insulin-enhancing agent. The complex was administered intragastrically to both normal and streptozotocin (STZ)-diabetic rats for two weeks. The results show that in STZ-diabetic rats the complex at a dose of 10.0 and 20.0 mg V kg−1, could lower the basal blood glucose level in rats and improve the response to an ig glucose challenge. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats.