Synthesis and biological activity of dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazins

Reaction of 2-guanidinobenzimidazole with halogenated active methylenes and ketones gave dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo [1,2-a][1,3,5]triazin derivatives in very good yield. The anti-bacterial evaluation of the newly synthesized products against broad spectrum of bacteria was performed. Most of products showed high inhibitory effect. All compounds have been characterized based on IR, 1H NMR, 13C NMR and Mass spectra.

Reaction of 2-guanidinobenzimidazole with halogenated active methylenes and ketones gave dihydroimidazole and 3,4-dihydrobenzo [4,5]imidazo [1,2-a][1,3,5]triazin derivatives. The anti-bacterial evaluation of the synthesized products showed excellent zone of inhibition against tested bacteria.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of dihydroimidzole and [1,3,5]triazins derivatives.
► All compounds good yields, short time and simplicity in the experimental procedure.
► The synthesized compounds showed excellent zone of inhibition against tested bacteria.
► All compounds have been characterized based on IR, 1H, 13C NMR, and mass spectrum.