کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1395955 | 1501169 | 2012 | 7 صفحه PDF | دانلود رایگان |
Sixteen carbazole alkaloids from Clausena vestita D. D. Tao were extracted, and their anti-tumor activities were evaluated. Among the extracts, Clauszoline-I exhibited an obvious growth inhibitory activity against several cancer cell lines through its ability to induce cell cycle arrest in the S and G2/M phases. A dramatic morphologic change with decreased F-actin staining and RhoA activity was found in Clauszoline-I treated HepG2 cells, in which the phosphorylation of PKCδ (Ser643) was inhibited. Our results indicated that induction cell cycle arrest by Clauszoline-I might be achieved by decreasing the RhoA activity via the inhibition of PKCδ phosphorylation.
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► Clauszoline-I is a carbazole alkaloid from Clausena vestita D. D. Tao.
► It induced cell cycle arrest and Chk1 redistribution from nucleus into cytoplasm.
► It caused morphological changes via repression of RhoA activation.
► It inhibited PKCδ (Ser643) phosphorylation.
Journal: European Journal of Medicinal Chemistry - Volume 47, January 2012, Pages 214–220