کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1395965 | 1501169 | 2012 | 11 صفحه PDF | دانلود رایگان |
1,3-Dipolar cycloaddition reaction of 1-aryl-1H-pyrrole-2,5-diones 1a-e with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 2a–c and sarcosine (3) in refluxing ethanol, afforded 4′-aryl-5′a,6′-dihydro-1′-methyl-spiro[3H-indole-3,2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH,4′H)-triones 4a–o in good yields. Compound 4l exhibited high anti-tumor activity against HEPG2 (liver cancer) cell line (IC50 = 12.16 μM) compared to that of Doxorubicin (IC50 = 7.36 μM), and the other synthesized compounds revealed moderate anti-tumor properties against HCT116 (colon), MCF7 (breast) and HEPG2 (liver) human tumor cell lines. 3D-Pharmacophore modeling and quantitative structure-activity relationship (QSAR) analysis were combined to explore the structural requirements controlling the observed anti-tumor properties. It was found that the major structural factors affecting potency of these compounds were related to their basic skeleton.
Anti-tumor active 4′-aryl-5′a,6′-dihydro-1′-methyl-spiro[3H-indole-3,2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH,4′H)-triones were synthesized via dipolar cycloaddition reaction of azomethine ylides with 1-aryl-1H-pyrrole-2,5-diones.Figure optionsDownload as PowerPoint slideHighlights
► Spiro[3H-indole-3,2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH,4′H)-triones were prepared.
► Antitumor properties of the synthesized compounds were screened.
► QSAR studies were conducted to understand the observed anti-tumor properties.
Journal: European Journal of Medicinal Chemistry - Volume 47, January 2012, Pages 312–322